Background: Serious inhaler technique errors can impair drug delivery to the lungs. This randomised, crossover,\nopen-label study evaluated the proportion of patients making predefined serious errors with Pulmojet compared\nwith Diskus and Turbohaler dry powder inhalers.\nMethods: Patients ââ?°Â¥18 years old with asthma and/or COPD who were current users of an inhaler but naÃ?¯ve to the\nstudy devices were assigned to inhaler technique assessment on Pulmojet and either Diskus or Turbohaler in a\nrandomised order. Patients inhaled through empty devices after reading the patient information leaflet. If serious\nerrors potentially affecting dose delivery were recorded, they repeated the inhalations after watching a training\nvideo. Inhaler technique was assessed by a trained nurse observer and an electronic inhalation profile recorder.\nResults: Baseline patient characteristics were similar between randomisation arms for the Pulmojet-Diskus (n = 277)\nand Pulmojet-Turbohaler (n = 144) comparisons. Non-inferiority in the proportions of patients recording no\nnurse-observed serious errors was demonstrated for both Pulmojet versus Diskus, and Pulmojet versus Turbohaler;\ntherefore, superiority was tested. Patients were significantly less likely to make ââ?°Â¥1 nurse-observed serious errors using\nPulmojet compared with Diskus (odds ratio, 0.31; 95 % CI, 0.19ââ?¬â??0.51) or Pulmojet compared with Turbohaler\n(0.23; 0.12ââ?¬â??0.44) after reading the patient information leaflet with additional video instruction, if required.\nConclusions: These results suggest Pulmojet is easier to learn to use correctly than the Turbohaler or Diskus for\ncurrent inhaler users switching to a new dry powder inhaler.
Loading....